Current Issue : April-June Volume : 2026 Issue Number : 2 Articles : 6 Articles
Background: Current histopathology- and molecular-based gold standards for diagnosing adult diffuse gliomas (ADGs) have inherent limitations in reproducibility and interobserver concordance, while being time-intensive and resource-demanding. Although hyperspectral imaging (HSI)-based computer-aided pathology shows potential for automated diagnosis, it often yields suboptimal accuracy due to the lack of complementary spatial and structural tumor information. This study introduces a multimodal fusion framework integrating HSI with routinely acquired preoperative magnetic resonance imaging (MRI) to enable automated, high-precision ADG diagnosis. Methods: We developed the Hyperspectral Attention Fusion Network (HAFNet), incorporating residual learning and channel attention to jointly capture HSI patterns and MRI-derived radiomic features. The dataset comprised 1931 HSI cubes (400–1000 nm, 300 spectral bands) from histopathological patches of six major World Health Organization (WHO)-defined glioma subtypes in 30 patients, together with their routinely acquired preoperative MRI sequences. Informative wavelengths were selected using mutual information. Radiomic features were extracted with the PyRadiomics package. Model performance was assessed via stratified 5-fold cross-validation, with accuracy and area under the curve (AUC) as primary endpoints. Results: The multimodal HAFNet achieved a macro-averaged AUC of 0.9886 and a classification accuracy of 98.66%, markedly outperforming the HSI-only baseline (AUC 0.9267, accuracy 87.25%; p < 0.001), highlighting the complementary value of MRI-derived radiomic features in enhancing discrimination beyond spectral information. Conclusions: Integrating HSI biochemical and microstructural insights with MRI radiomics of morphology and context, HAFNet provides a robust, reproducible, and efficient framework for accurately predicting 2021 WHO types and grades of ADGs, demonstrating the significant added value of multimodal integration for precise glioma diagnosis....
Background Hepatic artery pseudoaneurysms (HAP) and hepatic haemangiomas (HH) may present with indistinguishable imaging characteristics, particularly when clinical history favors one diagnosis over the other. Primary imaging alone may be insufficient for definitive differentiation. This case highlights the importance of further non-invasive imaging modalities in avoiding unnecessary invasive procedures if clinical condition allows. Case presentation A 55-year-old patient presented with abdominal trauma after a fall. Computed tomography (CT) revealed a grade III liver laceration with a hyper vascular lesion near the right hepatic artery, initially suspected to be a HAP. Trans-arterial embolization (TAE) was planned, and selective catheterization was performed. However, angiography showed no pseudoaneurysm filling but rather features suggestive of a haemangioma, leading to the abortion of the procedure. Subsequent magnetic resonance imaging (MRI) confirmed a flash-filling HH. The patient remained stable, with no haemorrhagic complications or need for further intervention. Conclusion In emergencies, recognizing imaging features distinguishing haemangiomas from pseudoaneurysms is crucial to avoid unnecessary invasive procedures, especially in stable patients, using accurate non-invasive tools like CT or MRI....
Background and Objective: Adolescent bipolar disorder (BD) has substantial symptom overlaps with other psychiatric disorders. Identifying its distinctive candidate neuroimaging markers may be helpful for exploratory early differentiation and to inform future translational studies after independent validation. Methods: This cross-sectional study enrolled adolescents with BD and age- and sex-matched healthy controls. Assessments included clinical/behavioral scales and an emotional Go/NoGo task-based fMRI (Go trials require a response; NoGo trials require response inhibition) acquired across three mood states (depression, mania, and remission) and matched controls. We applied several conventional machine learning classifiers to task-fMRI data to classify BD versus healthy controls and to identify the most relevant neuroimaging predictors. Results: A total of 43 adolescents with BD (15 in remission, 11 with depression, and 17 with mania) and 43 matched healthy controls were included. Under the Go-NoGo condition, activation-derived features in the remission state showed the strongest discrimination, with RF achieving the best performance (accuracy = 94.29%, AUC = 98.57%). These findings suggest that task-evoked functional alterations may remain detectable during remission. In addition, activation paerns in regions within the limbic system, prefrontal cortex, and default mode network were significantly correlated with clinical scales and behavioral measures implicating these regions in emotion regulation and cognitive functioning in adolescents with BD. Conclusion: This study showed that adolescents with BD during remission without manic and depressive symptoms may still have aberrant neural activity in the limbic system, prefrontal cortex, and default mode network, which may serve as a potential candidate neuroimaging signature of adolescent BD....
Background Benign prostatic hyperplasia (BPH) is the most common urological disorder in older males, often treated with prostate artery embolization (PAE) to alleviate lower urinary tract symptoms. While traditional embolic materials like microspheres are common, issues such as symptom recurrence and non-target embolization remain. This systematic review evaluates the safety and effectiveness of n-butyl cyanoacrylate (NBCA) glue as an alternative embolic agent for PAE. Materials and methods A thorough search was performed across databases including PubMed, ScienceDirect, Cochrane, Google Scholar, Scopus, and MEDLINE. Studies were included if they assessed NBCA glue for PAE in BPH patients. Exclusions were made for reviews, non-English articles, conference abstracts, and studies not using glue or ethiodized oil mixtures. The Methodological Index for Non-Randomized Studies criteria was used to assess bias risk, and due to varied outcome measures, a narrative synthesis was conducted. Results Six studies involving 667 patients met the inclusion criteria. The age in mean ± SD across studies ranged from 67.5 ± 7.8 to 72.6 ± 10.5 with most patients presenting with moderate to severe BPH unresponsive to medication. NBCA glue-based procedures showed high technical success rates and shorter procedure times. International Prostate Symptom Score improvement was reported in 83–94% of patients across all studies with associated quality of life significantly enhanced in up to 94% of patients as well. Prostate volume reduction ranged from 11% to 40.5%, depending on follow-up duration. PSA levels and medication use decreased, and erectile function was mostly preserved, though results varied. Minor complications like groin hematomas and post-embolization syndrome occurred in 4–22% of patients, with no major adverse events reported. Conclusion This review assesses NBCA-based glue as a potential embolic agent in PAE for BPH. The evidence suggests promising short-term outcomes with a favorable safety profile, though findings remain preliminary due to small sample sizes and short follow-up. Larger multicenter randomized trials are therefore needed to validate these results and guide clinical practice....
Background There have been several analyses conducted demonstrating a sharp decrease in general physician fulfillment and satisfaction. Other studies have demonstrated that burnout, anxiety, and moral injury are prevalent among interventional radiologists specifically, however there is a paucity of literature examining professional fulfillment within the profession. The purpose of this study was to characterize professional fulfillment through job, career, and specialty satisfaction scores among interventional radiologists using a validated assessment tool. Results There were 106 respondents included in the analysis: 97 (91.5%) practicing interventional radiologists and 9 (8.5%) interventional radiology trainees, including 87 (82.1%) males and 19 (17.9%) females. Respondents included those in academic (40; 37.7%), private practice (46; 43.4%), and hybrid/other settings (20; 18.9%), as well as at various lengths of practice. The mean job satisfaction score was 3.48, with 38 (35.8%) of respondents expressing a mean score of ≥ 4, which has been established as being “satisfied”. The mean career satisfaction score was 3.40, with 38 (35.8%) of respondents reporting a mean score of ≥ 4. The mean global specialty satisfaction was 3.63 with 53 (50.0%) of respondents reporting a mean score of ≥ 4. Conclusions Professional fulfillment is low among interventional radiologists, with half expressing global specialty satisfaction and with minority percentages signaling job and career satisfaction. Patient interaction and work-life balance were identified as significant factors positively affecting professional fulfillment....
Acute kidney injury and other organ dysfunction in the setting of heart failure are primarily determined by a low cardiac output status and venous congestion, which is a sequence of increases in heart filling pressures. Early point-of-care ultrasound assessment of the inferior vena cava, lung ultrasound for pulmonary congestion, and focused echocardiography have become increasingly used in the bedside evaluation of congestive heart failure and assessment of the left ventricle. The congestion disrupts venous outflow in abdominal organs, most notably the kidneys and liver, and can be noninvasively evaluated with Doppler ultrasound, known as the venous excess. Such flow abnormalities have been repeatedly linked to congestive organ dysfunction and poorer clinical outcomes. In this review, we outline a thorough, bedside approach to assessing venous congestion using Doppler imaging. Venous Excess Ultrasound (VExUS) is an emerging protocol that offers a point-of-care ultrasonic method for grading systemic congestion and tailoring diuretic management. The purpose of this review is to evaluate VExUS's potential applications and critically appraise current evidence on its effectiveness in directing decongestive therapy for patients with acute decompensated heart failure. In conclusion, multiple Doppler venous congestion assessment emerges as a promising, noninvasive tool for the instantaneous assessment of organ congestion in cardiorenal syndrome, helping in the management of fluid and diuretic administration. Its accuracy, however, depends on the sonographer's proficiency. Larger-scale studies are needed to confirm their applicability in clinical practice...
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