Current Issue : January-March
Volume : 2023
Issue Number : 1
Articles : 1 Articles
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, improve solubility of drugs that are less soluble in a high pH environment. The aim of the present study was to develop a delivery system wherein the retention lumafentrine could be achieved for increasing local action in the gastric region. Various formulations of floating beads of lumafentrine were developed using polymers like Chremophore RH 40, H-p-Beta-Cyclodextrine, sodium deoxycholate, soluplus, PVP K-30, PVP K-60, sodium taurocholate and carbapol. The beads were prepared by emulsion gelation method. The results showed that beads formulated with mixture of drug and polymer (F3) showed the highest drug release compared to other formulations. So the formulation F3 was selected for stability studies according to ICH guidelines for a period of three months....
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