Current Issue : October-December
Volume : 2023
Issue Number : 4
Articles : 1 Articles
The present study aims to design a novel drug delivery system containing salicylic acid microsponges and prepare microsponge gel. Salicylic acid is acatalytic compound that for several skin conditions caused by thickened, hard skin, such as warts, verrucas, psoriasis, scaly skin conditions and some nail infections. The microsponge delivery system is a unique technology for the controlled release of active agents. The microsponges were prepared by quasi-emulsion solvent diffusion method by using polymer eudragit S-100 and ethyl cellulose. All the optimized microsponges were subjected to various evaluation parameters such as production yield, encapsulation efficiency, particle size analysis and in-vitro drug release study. The Fourier transform infrared radiation measurement (FTIR) and Differential scanning calorimetry (DSC) of drug and excipient confirm compatibility. The highest drug release for F3 and F7 optimized formulation was found to be 87.12% and 87.84 % respectively for the 10h. The optimized microsponge gel formulation MGI (F7) showed the controlled release of salicylic acid for 10h. The drug release data of optimized batch MGI (F7) were fitted into different kinetic models and showed that the drug release from gel formulation follows zero-order release. As compared to conventional formulation, the prepared microsponge gel is expected to remain on the skin for a longer time, gradually releasing its contents over time. Hence, microsponges and microsponge gel prepared in this study are promising as being more useful than conventional formulation therapy....
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