Current Issue : January-March
Volume : 2024
Issue Number : 1
Articles : 1 Articles
Hypertension, a prevalent cardiovascular disorder, exhibits a circadian rhythm with increased blood pressure during certain periods, emphasizing the need for time-specific drug delivery systems. This research focuses on the formulation and evaluation of a chronopharmaceutical-based pulsatile drug delivery system tailored for hypertension management. The study aims to optimize drug release patterns to coincide with the peak blood pressure periods, thus enhancing therapeutic efficacy and minimizing side effects. The formulation process involves the selection of suitable polymers and excipients to create a time-dependent drug release profile. Various polymer combinations are explored to achieve pulsatile release, considering factors such as drug solubility, stability, and biocompatibility. The developed system incorporates a programmable pulsatile release mechanism, allowing for precise control over drug delivery timing. In vitro and in vivo evaluations are conducted to assess the performance and efficacy of the formulated chronopharmaceutical system. Dissolution studies investigate the release kinetics under simulated physiological conditions, while stability studies assess the system's robustness over time. Pharmacokinetic studies are carried out in animal models to evaluate the bioavailability and pharmacological response of the developed formulation compared to conventional sustained-release formulations. Furthermore, biocompatibility and safety assessments are conducted to ensure the absence of adverse reactions or toxic effects. The research also explores patient compliance and acceptability through surveys and feedback mechanisms, providing valuable insights into the practicality and user-friendliness of the proposed pulsatile drug delivery system. The findings of this study have the potential to revolutionize hypertension management by introducing a tailored chronopharmaceutical approach. The optimized formulation not only aligns with the circadian rhythm of hypertension but also offers improved patient compliance and reduced side effects. The research contributes to the advancement of drug delivery science, providing a foundation for the development of personalized and effective treatment strategies for cardiovascular diseases....
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