Background: Gingivitis and periodontitis are progressive inflammatory diseases affecting the tissues surrounding the teeth; gingivitis involves reversible gingival inflammation, whereas periodontitis is a more advanced condition characterized by irreversible tissue destruction, including clinical attachment and alveolar bone loss. Salusin-α and salusin-β are inflammation-related polypeptides that may reflect periodontal inflammatory burden; however, salivary data in periodontal diseases are lacking. This study aimed to evaluate the salivary salusin-α and salusin-β levels in individuals with gingivitis and periodontitis. Methods: Saliva samples were collected from a total of 80 systemically healthy non-smoker individuals classified into three groups: gingivitis (n = 27), stage III grade B periodontitis (n = 27), and healthy participant (n = 26) based on the 2017 Periodontal Classification criteria. Salusin-α and salusin-β levels in saliva were quantified using enzyme-linked immunosorbent assays (ELISA). Statistical analysis utilized one-way ANOVA, Student’s t-test, and Receiver Operating Characteristic (ROC) curve analysis. Results: Compared to the healthy group, salivary levels of salusin-α and salusin-β were found to be significantly elevated in periodontitis groups (p < 0.05), not gingivitis (p > 0.05); moreover, the increase in both markers was significantly greater in the periodontitis group than in the gingivitis group (p < 0.05). Conclusions: Our finding suggests that salusins play a role in the inflammatory processes of periodontal diseases. The increase in salusin-α and salusin-β levels in the periodontitis suggests that these parameters may serve as biomarkers.
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