The spectroscopic method (in methanol – second derivative zero crossing method) has been developed, which were novel, simple, accurate, reproducible, economical and validated for the determination of clobetasol propionate and miconazole nitrate in cream. The drug is extracted from cream by sonication, heating, cooling. Absorbance of miconazole nitrate and clobetasol propionate were measured at 266 nm (zero crossing point of clobetasol propionate) and 282 nm (zero crossing point of miconazole nitrate), respectively and show linearity over the range of 4-24 μg/ml for clobetasol propionate and 160-960 μg/ml for miconazole nitrate with correlation coefficient 0.9996 and 0.9994 for clobetasol propionate and miconazole nitrate in respectively. LOD and LOQ were found to be 0.20 μg/ml and 0.60 μg/ml for clobetasol propionate respectively and 6.17 μg/ml and 18.17 μg/ml for miconazole nitrate, respectively.
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