A simple and sensitive RP-HPLC method has been developed for the estimation of ilaprazole (ILA) and domperidone (DOM) in their capsule dosage form in the ratio of 1:3. The method was carried on a C18 (250 × 4.6 mm, 5 μm) column with a mobile phase consisting of methanol and water in the ratio (80:20 v/v) and flow rate 0.9 ml min-1. The detection was carried out at 289 nm. The retention time for ILA and DOM were found to be 4.644 and 7.232 min respectively. The ILA and DOM followed linearity in the concentration range of 50 – 150 μg/ml and 150 – 450 μg/ml respectively. The developed method was validated for precision, accuracy, sensitivity and robustness. The developed method can be used for routine analysis of these drugs in combination in the capsule formulations.
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