A simple and sensitive first order derivative spectrophotometric method has been developed for the estimation of ilaprazole (ILA) and domperidone (DOM) in their capsule dosage form in the ratio of 1:3. The estimation of ILA and DOM was carried out on a UV/VIS spectrophotometer using 1 cm quartz cell. The method was performed at 282 nm and 285 nm as a zero crossing point for ILA and DOM respectively. ILA and DOM obeyed beer’s law in a concentration range of 5 – 25 (0.9990) μg/ml and 15 – 75 μg/ml (0.9991) respectively. The average percentage recovery of ILA and DOM was found to be 100.10% and 100.71 % respectively. The LOD and LOQ value were found to be 0.78 and 2.38 ppm for ilaprazole and 1.25 and 3.79 ppm for domperidone respectively. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form.
Loading....