A simple, accurate and precise Q-absorbance Ratio spectrophotometric method for the simultaneous estimation of Paracetamol and Tapentadol HCl in Bulk and Pharmaceutical Dosage forms has been developed and validated. The method is based on Q-absorption Ratio method using two wavelengths, 289 nm (λ max of Paracetamol) and 242.5 nm (Iso-absorptive point). 0.1 N Sodium Hydroxide was used as a solvent in this method. The method was validated with respect to linearity, accuracy, precision as per the International Conference on Harmonisation (ICH) guidelines. The drug response with respect to absorbance was linear over the concentration range 5-35 µg/ml for Paracetamol and 3-15 µg/ml for Tapentadol Hydrochloride. The percentage recovery of Paracetamol and Tapentadol Hcl was found to be 99.45% and 99.10% respectively. The %R.S.D. values for intra-day and inter-day precision study were <2.0%, confirming that the method was sufficiently precise. The method can be successfully employed for the simultaneous determination of Paracetamol and Tapentadol HCl in pharmaceutical formulations.
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