Zero-order UV-Spectrophotometric methods have been developed and validated for the estimation of Nizatidine in bulk and its tablet formulations. The solutions of standard and sample were prepared in water. Nizatidine was estimated at 327 nm for the zero order UV-Spectrophotometric method. Beer’s law was obeyed in the concentration range of 2-10 μg/ml with r2 value 0.999 for zero order. This method was tested and validated for various parameters according to ICH guidelines. The proposed method was successfully applied for the determination of Nizatidine in tablet formulations.
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