UV Spectrophotometric method has been developed for simultaneous estimation of Ceftazidime (CTZ) and Clavulanic acid (CA) in bulk drug and in Pharmaceutical dosage form. This method utilizes distil water as a solvent and λmax of Ceftazidime and Clavulanic acid is selected for analysis was found to be 256 nm and 278 nm respectively. Linearity was observed in the concentration range of 4-20 μg/ml for Ceftazidime (r2=0.9991) and 50-250 μg/ml for Clavulanic acid (r2=0.9983). The method was validated statistically and by recovery studies. The mean % recovery was 99.87-99.89 % and 99.75-100.35 % for Ceftazidime and Clavulanic acid respectively. Developed method was applied to pharmaceutical dosage form. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive.
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