A simple, accurate and precise UV spectrophotometric method for the simultaneous estimation of Aspirin and Esomeprazole magnesium in Bulk and Pharmaceutical Dosage forms has been developed and validated. The method is based on simultaneous method using two wavelengths, 274 nm (λmax of Aspirin) and 302 nm (λmax of Esomeprazole). Methanol was used as a solvent in this method. The method was validated with respect to linearity, accuracy, precision as per the International Conference on Harmonisation (ICH) guidelines. The drug response with respect to absorbance was linear over the concentration range 20-50 µg/ml for Aspirin and 5-30 µg/ml for Esomeprazole magnesium. The percentage recovery of Aspirin and Esomeprazole magnesium was found to be 99.62% and 99.79% respectively. The % R.S.D. values for intra-day and inter-day precision study were <2.0%, confirming that the method was sufficiently precise. The method can be successfully employed for the simultaneous determination of Aspirin and Esomeprazole magnesium in pharmaceutical formulations.
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