A new, simple, accurate, precise, rapid, selective and reproducible high performance thin layer chromatographic method (HPTLC) for quantitative analysis of Zaltoprofen in pharmaceutical formulations has been established and validated. HPTLC on aluminium - backed silica gel 60F254 plates with chloroform: methanol, 8.5:1.5 (v/v) as mobile phase was followed by densitometry measurement at 258 nm. This system was found to give compact bands for Zaltoprofen at Rƒ 0.65. Calibration plots were linear in the range 100-600 ng per band with correlation coefficient 0.998. The recovery was in the range of 99.61-100.51%. The method was validated in accordance with ICH guidelines and can be used for analysis of marketed formulations.
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