A simple, precise, accurate, reproducible Simultaneous equation UV Spectroscopic method was developed for the simultaneous estimation of Montelukast Sodium and Olopatadine Hydrochloride in Combined dosage form using methanol. The wavelength maximum for Montelukast sodium and Olopatadine Hydrochloride was selected to be 283 nm and 304 nm. The method was found to be linear in the range of 10-50 μg/ml (r2=0.9991) for Montelukast sodium at 283 nm and the range of 5-25 μg/ml (r2=0.9992) for Olopatadine Hydrochloride at 304 nm. The proposed method was validated for linearity, precision, accuracy and ruggedness according to ICH guideline for routine estimation purpose of these drugs in combined bulk dosage form. Since this method has been developed and validated to ensure that the performance characteristic of the method meets the requirements for the intended analytical applications.
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