The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of Diclofenac Potassium and Febuxostat in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectrum was obtained in 0.1 N NaOH and the determinations were made at 282.12 nm (ZCP of Febuxostat) for Diclofenac Potassium and 255.17 nm (ZCP of Diclofenac Potassium) for Febuxostat. The linearity was obtained in the concentration range of 5-25 μg/ml for Diclofenac Potassium and 2-10 μg/ml for Febuxostat. The mean recovery was 98.86-100.16% and 99.63-100.67% for Diclofenac Potassium and Febuxostat, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of Diclofenac Potassium and Febuxostat in pharmaceutical combined tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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