A new derivative spectroscopic method was developed and validated for the determination of Sildenafil citrate and Fluoxetine hydrochloride. Calibration curve for Sildenafil citrate and Fluoxetine hydrochloride over the concentration range 30-90 µg/ml were plotted and ZCP of Sildenafil citrate and Fluoxetine hydrochloride was found 226 nm and 263 nm respectively. The results of analysis have been validated statistically and by recovery studies. The value of standard deviation was satisfactory and recovery studies ranging from 99.03-100.0% for Sildenafil citrate and 100.25-100.93% for Fluoxetine hydrochloride were indicating of accuracy and precision of proposed method. The results of the assay are in good agreement with the label amount. The method was found to be simple, rapid, and accurate and can be adopted in routine analysis of Sildenafil citrate and Fluoxetine hydrochloride drugs in tablets.
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