A UV quantification spectrophotometric method was developed for detection of Diclofenac potassium which is economical, simple, safe, and specific. The samples were used for degradation studies by using the developed method. The absorbance maximum (λmax) of the Diclophenac potessium was found to be 209 nm. The method reveals high sensitivity, with linearity in the 2 to 10 µg/ml range. The lower limit of detection was found to be 0.05 µg/ml and the limit of quantification was found to be 0.15 µg/ml. All the calibration curves demonstrated a linear relationship between the absorbance and concentration, with the correlation coefficient higher than 0.99. The regression equation of the curve was Y=0.106x + 0.354. The precision of the method was found to be 1.430±0.02162. The % recovery was found to be 101.31%.
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