Lapatinib is an orally active drug for breast cancer and other solid tumours. It is used in combination therapy for HER-2 positive breast cancer. A simple and precise calorimetric method was developed for determination of Lapatinib in pharmaceutical dosage forms using MBTH reagent. Lapatinib exhibit λ max at 661 nm in solvent methanol and obeyed linearity in concentration range 2-10 µg/ml. The colorimetric reagent used is MBTH and the oxidising agent used is ferric chloride. The LOQ and LOD are found to be 0.36 and 0.121 mcg/ml respectively. The method is statistically validated.
Loading....