A new simple, sensitive and economic absorption ratio method was developed and validated for the determination of Eperisone hydrochloride and Diclofenac sodium in Bulk and pharmaceutical formulation. The method involves Q-absorption analysis based on the measurement of absorbance at two wavelengths, i.e. λ max of Eperisone hydrochloride (261.0 nm) and Iso-absorptive point of both drugs (280.0 nm). Beer’s law was obeyed in the concentration range between 3-24 μg/ml for Eperisone hydrochloride and 5-40 μg/ml for Diclofenac sodium. The solutions were prepared in distilled water. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible, less time consuming and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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