A simple and sensitive spectrophotometric method has been developed for simultaneous determination of Tolperisone hydrochloride and Diclofenac sodium in a combined pharmaceutical dosage form. In the proposed method, the absorbances were measured at 261.0 nm and 276.0 nm corresponding to the absorbance maxima of Tolperisone hydrochloride and Diclofenac sodium in Dist. Water respectively. Linearity range was observed in the concentration range of 4-24 μg/ml for Tolperisone hydrochloride and 5-30 μg/ml for Diclofenac sodium. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 261.0 nm and 276.0 nm and solving the simultaneous equation. Developed method was applied to pharmaceutical formulation. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise.
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