A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Dexketoprofen in bulk and pharmaceutical dosage form. An absorption maximum was found to be at 225 nm. The percentage recovery of Dexketoprofen was found to be 99.7169 % in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision, LOD, LOQ, Sandell’s sensitivity, molar absorbtivity, and specificity. Beer’s law was obeyed in the concentration range of 10-50 µg/ml having line equation y = 0.2238 x + 0.0212 with correlation coefficient of 0.9993.
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