A Simple, accurate, precise and sensitive first order derivative spectrophotometric method was developed and validated for the determination of cefixime trihydrate and dicloxacillin sodium in combine tablet dosage forms. First order derivative spectrophotometric method is adopted to eliminate spectral interference. Cefixime trihydrate and dicloxacillin sodium have λmax at 283 nm and 276 nm respectively in methanol solvent. The method was found to be linear and obeys beer’s law in concentration range of 12-32 µg/ml for both cefixime trihydrate and dicloxacillin sodium. The developed method was validated as per ICH guidelines.
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