Frequency: Quarterly E- ISSN: 0976-7584 P- ISSN: 2229-4147 IBI Factor: 4, H-Index: 1, RI Factor 2.24, Global Impact Factor 0.76 (2015) Abstracted/ Indexed in: CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Impact: NDDS" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under novel drug delivery systems. It welcomes articles pertaining to nano drug delivery systems; gastroretensive system, colonic drug delivery, bioadhesive and mucoadhesive systems; nasopulmonary drug delivery; ocular delivery; transdermal delivery, implants and inserts; protein and peptide delivery; manufacturing, quality control and regulatory aspects of NDDS, etc.
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that\ncan be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to\nutilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties.\nAs such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated\nin 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional\nmonolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns.\nThe possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen,\nwas also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve\ncustomised drug release patterns, whereby one drug was released immediately from a Kollicoat\nInstant Release matrix, whilst the effect of the second drug was sustained over an extended time\nspan using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate\nsmall and intricate formulations containing multiple active pharmaceutical ingredients with distinct\nrelease properties....
Advanced external preparations that possess a sustained-release effect and integrate few irritant elements are urgently needed to satisfy the special requirements of topical administration in the clinic. Here, a series of liquid pillar[n]arene-bearing varying-length oligoethylene oxide chains (OEPns) were designed and synthesized. Following rheological property and biocompatibility investigations, pillar[6]arene with triethylene oxide substituents (TEP6) with satisfactory cavity size were screened as optimal candidate compounds. Then, a supramolecular liquid reservoir was constructed from host–guest complexes between TEP6 and econazole nitrate (ECN), an external antimicrobial agent without additional solvents. In vitro drug-release studies revealed that complexation by TEP6 could regulate the release rate of ECN and afford effective cumulative amounts. In vivo pharmacodynamic studies confirmed the formation of a supramolecular liquid reservoir contributed to the accelerated healing rate of a S. aureus-infected mouse wound model. Overall, these findings have provided the first insights into the construction of a supramolecular liquid reservoir for topical administration....
Background: Resveratrol effects on the prevention and treatment of colon\ncancer have been well documented recently, but low solubility, rapid\nabsorption and metabolism of resveratrol limit its beneficial effects on colon\ncancer. Designing a formulation that enhances the solubility of resveratrol,\nprotects resveratrol from oxidation and isomerization, and delivers it to the\ncolon is a priority of food and drug industry. In this study, resveratrolpolyethylene\nglycol (PEG)-loaded pectin-chitosan polyelectrolyte complex\nwas designed as a colon targeted delivery system.\nMethods: The effects of adding PEG, ultra-sonication time, pH, and pectin to\nchitosan ratio were investigated on particle size, polydispersity index (PDI),\nzeta potential by particle size analyzer, and scanning electron microscopy\n(SEM). Encapsulation efficiency (EE), release of resveratrol in simulated\ngastrointestinal fluid, and different pHs were analyzed via High Performance\nLiquid Chromatography (HPLC). Antioxidant activity was measured by (2, 2-\ndiphenyl-1-picryl-hydrazyl-hydrate) DPPH free-radical method.\nResults: Results showed that colloidal stable micro-particles (725 �± 20 nm)\nwith PDI < 0.3 and zeta potential +27 �± 2 mV was formed in the ratio of 5:1\nof pectin to chitosan w/v % after a 10-min sonication. Encapsulation\nefficiency was 81 �± 7 %. The reduction of antioxidant activity of resveratrol\nloaded micro-particles after one month was less than 13%. Micro-particles\nreleased about 33% of resveratrol in the simulated gastric and intestinal fluids.\nConclusion: Two-thirds of the loaded resveratrol in Pectin-Chitosan complex\nreached colon. The developed system had enough specification for enriching\nfruit based drinks due to remarkable colloidal stability in the pH range of 3.5\nto 4.5....
Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up....
Aqua Gel is a network of polymer chains that are water-insoluble, sometimes found as a colloidal gel in which water is the dispersion medium and also sometime they are in the form of cross linked polymer networks that absorb substantial amounts of aqueous solutions. Aqua Gels have been introduced suitable as novel materials for a variety of applications such as biomedical engineering, sanitary products, agriculture, bioseparation, enhanced oil recovery, etc. They have been successfully used as superabsorbent materials and in drug delivery, cell encapsulation and tissue repair due to their high water content and consequent biocompatibility. The rate and degree of Aqua Gel swelling are the most important parameters which control the release patterns of solvents and drugs from these polymeric networks. PH sensitive and temperature sensitive Aqua Gels can be used for site specific controlled drug delivery. Aqua Gels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. The aim of this article is to present a concise review on the applications of Aqua Gels in the pharmaceutical field, Aqua Gel properties, and method of preparation of Aqua Gel, advantages and disadvantages of Aqua Gel....
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive\nproperty to abnormal physiological environment as well as the original property to normal physiological environment. However,\nthe drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pHsensitive\ncomposite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated\nÃ?²-cyclodextrin (Ac-Ã?²-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic\nresponse. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure\nAc-Ã?²-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-Ã?²-CD. Furthermore, the structural\ninformation was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite\nnanoparticle possessed structural characteristic of both Ac-Ã?²-CD and Fe3O4. Composite nanoparticle exhibited sphere and\ntwo-phase morphology with the diameter of about 200ââ?¬â??250nm depending on their detection method and zeta potential of âË?â??12\nto âË?â??14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in\nneutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug\nloading and release behavior were investigated through preliminary in vitro evaluation....
Hydrogels are among the most common materials used in drug delivery, as polymeric\nmicelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this\npaper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with\nthe specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination\ntherapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking\nof a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically\ndegraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles\nwere physicochemically characterized and subjected to UV irradiation to form what we called the\nâ??nanogridsâ?. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and\nbeclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug\nwas specifically assessed to verify that it can spread along the hydrophilic portions and, therefore,\neffectively released. These systems can open new pharmaceutical applications for known hydrogels\nor micelle systems, considering that in literature only few examples are present....
Cathepsin D is an aspartic protease and one of the most abundant proteases. It is overexpressed in many cancers and plays an important role in tumor development, progression, and metastasis. While it is a physiologically intracellular protein, cathepsin D is secreted into the extracellular matrix under pathological conditions, making it an appealing target for drug delivery systems. Here, we present the development and evaluation of a new delivery system for tumor targeting based on immunoliposomes functionalized with pepstatin A—a natural peptide inhibitor of cathepsin D. A lipid tail was added to pepstatin A, enabling its incorporation into the liposomal lipid bilayer. The successful targeting of cathepsin D was confirmed using recombinant cathepsin D and in tumor cell lines, showing the feasibility of this targeting approach and its potential for in vivo use in theragnostic applications....
In this study efforts were made to design matrix tablet containing superporous hydrogel particles (SPHPs) for sustained delivery of Ranitidine hydrochloride. The SPHPs were prepared from superporous hydrogel of poly(AM-co-AA). The characterization studies for SPH were performed by measurement of apparent density, porosity, swelling studies, and scanning electron microscopy (SEM) studies. SEM images clearly indicated the formation of interconnected pores, and capillary channels. The SPHPs were found to be low dense, highly porous and highly swellable. The prepared tablet floated and delivered the Ranitidine hydrochloride for about 12 hour. To ascertain the kinetics of drug release, the dissolution profiles were fitted to mathematical models that include zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, Weibull, and Hopfenberg. The in vitro drug release from proposed system was best explained by the Hopfenberg model indicating that the release of drug from tablets displayed heterogeneous erosion. It is concluded that the proposed gastroretentive drug-delivery system based on SPHPs is promising for stomach specific delivery of Ranitidine hydrochloride....
Metformin is a first-line drug for the clinical treatment of type 2 diabetes; however, it always leads to gastrointestinal tolerance, low bioavailability, short half-life, etc. Liposome acts as an excellent delivery system that could reduce drug side effects and promote bioavailability. Hyodeoxycholic acid, a cholesterol-like structure, can regulate glucose homeostasis and reduce the blood glucose levels. As an anti-diabetic active ingredient, hyodeoxycholic acid modifies liposomes to make it overcome the disadvantages of metformin as well as enhance the hypoglycemic effect. By adapting the thin-film dispersion method, three types of liposomes with different proportions of hyodeoxycholic acid and metformin were prepared (HDCA:ME-(0.5:1)-Lips, HDCA:ME-(1:1)- Lips, and HDCA:ME-(2:1)-Lips). Further, the liposomes were characterized, and the anti-type 2 diabetes activity of liposomes was evaluated. The results from this study indicated that three types of liposomes exhibited different characteristics—Excessive hyodeoxycholic acid decreased encapsulation efficiency and drug loading. In the in vivo experiments, liposomes could reduce the fasting blood glucose levels, improve glucose tolerance, regulate oxidative stress markers and protect liver tissue in type 2 diabetic mice. These results indicated that HDCA:ME-(1:1)-Lips was the most effective among the three types of liposomes prepared and showed better effects than metformin. Hyodeoxycholic acid can enhance the hypoglycemic effect of metformin and play a suitable role as an excipient in the liposome....
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