Journal Scope
Inventi Rapid/Impact: NDDS is the peer reviewed journal of Pharmaceutical Sciences. The articles deliver the knowledge about
modern technology in drug formulations. Nano drug delivery systems, gastroretensive system, colon drug delivery, bioadhesive and mucoadhesive systems, nasopulmonary drug delivery, ocular drug delivery, transdermal delivery and implants and inserts, osmotically regulated system, protein and peptides delivery, colloidal drug carrier systems, solid dispersion or dissolving system including all aspects of Noval drug delivery system are the areas covered in this journal.
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FORMULATION AND EVALUATION OF VALSARTAN CONTROLLED RELEASE TABLETS USING HPMC K15M ALONG WITH COPAL GUM
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S Vidyadhara, J Ramesh Babu, K Saideepika, G Swethanjali
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Valsartan was formulated as oral-controlled release matrix tablets using hydrophilic polymer such as hydroxypropyl methyl cellulose K15M (HPMC K15M) along with natural gum such as Copal gum. In this work a new attempt was made for in situ interactions between drug and polymers were devised to control the release of poorly water soluble drugs from oral hydrophilic monolithic systems. Polymers such as HPMC K15M and natural gum such as Copal gum were used at different concentrations in various formulations, while drug was maintained constantly in all the formulations. These polymers were used to monitor matrix swelling and gel properties. These findings indicated that the swelling and gel formation in the presence of ionizable species within the hydrophilic matrices provide an attractive alternative for controlled drug delivery from a simple monolithic system....
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MODIFICATION, IN-VITRO AND IN-VIVO EVALUATION OF MICROEMULSIONBASED HYDROGEL FORMULATION OF ACYCLOVIR FOR TOPICAL DELIVERY
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Deepak Sharma, Ranveer Singh Tomar, Deepak N Kapoor
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The purpose of this study was to investigate microemulsion-based hydrogel (MBH) as a topical delivery system for acyclovir. Topical delivery of acyclovir in the forms of microemulsion, MBH and the commercial cream was evaluated in vitro and in vivo. The results of permeation test in-vivo in mice showed that compared with the commercial cream, MBH and microemulsion could significantly increase the permeation of acyclovir into both epidermis and dermis. Stability test showed that MBH stored at 4 ?C for 3 months had no significant change in physicochemical properties. Skin irritation test in rabbit demonstrated that single application or multiple applications of MBH did not cause any erythema or edema, slight skin irritation for microemulsion. Microstructure changes of skins after administration observed under light microscope and scanning electron microscope (SEM) might result from the interaction of the ingredients of microemulsion with skins, which was related with the permeation enhancement of acyclovir. It can be concluded that the MBH could be a promising vehicle for topical delivery of acyclovir....
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NOVEL TRANSDERMAL DRUG DELIVERY IONTOPHORESIS: A REVIEW
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Tanpure Chandraprakash, Gopal Karva1, Katariya Vijay
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Skin is the largest organ of the body and protects from physical, chemical and biological grievance. It acts as barrier for permeation especially for hydrophilic and ionic drugs due to the lipophilic nature of the stratum corneum. Iontophoresis offers transfer of the molecules from stratum corneum to the systemic circulation by the application of the tolerable electricity. Iontophoresis provides pulsatile delivery of drug and avoids first pass metabolism of drug. The present review covers advantages, disadvantages and criteria of the drug selection for iontophoresis. This review also focuses on the principle and mechanism of iontophoresis. Pathways for iontophoretic transfer and iontophoretic devices are also included in this review. This review gives idea about factors affecting iontophoresis and conjugation of iontophoresis with other techniques. Formulation method used for the iontophoresis and in-vitro iontophoresis study are also covered....
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LIPOGEL: A NOVEL TOPICAL LIPOSOMAL DRUG DELIVERY SYSTEM
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Biraju D Patel, Dhaval V Patel, Jayant R Chavda, Nilesh K Patel
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In the formulation of topical dosage forms, attempts are being made to utilize drug carriers that ensure adequate localization or penetration of the drug within or through the skin in order to enhance the local and minimize the systemic effects, or to ensure adequate percutaneous absorption. The application of liposomes as drug carriers on the skin surface has been proven to be efficient in the delivery of liposome-entrapped drugs to and into the skin. Applied on the skin, liposomes may act as a solubilizing matrix for poorly soluble drugs, penetration enhancers, as well as a local depot for sustained drug release, at the same time diminishing the side effects of drugs. Summarily, topical liposome formulations could be more effective and less toxic than conventional formulations. However major limitation of using liposomes topically is the liquid nature of preparation. That can be overcome by their incorporation in adequate vehicles where original structure of vesicles is preserved. It has already been shown that liposomes are fairly compatible with gels made from polymers derived from crosslinked poly acrylic acid, such as carbopol resins....
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PREPARATION AND EVALUATION OF NANODISPERSION OF TELMISARTAN BY VARIOUS TECHNIQUES
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Jaiprakash B Gaja, F J Sayyad
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The purpose of this research work was to improve the solubility and dissolution rate of the telmisartan by dispersing drug in nanoparticles form in water soluble polymer at pH 7.5 (FDA recommended) using various nanodispersion techniques. Nanodispersion of telmisartan were prepared using PVP-K30 by various methods like solvent evaporation, antisolvent precipitation and spray drying in ratios 1:1 to 1:4.Saturation solubility, In-vitro dissolution, particle size distribution, FT-IR spectroscopy, PXRD, DSC and SEM studies were carried out. The results indicated that formulation containing 1:4 ratio of drug: PVP-K30 prepared by spray drying method showed the cumulative release of 99.84% as compared to 9.36 % for the pure drug in pH 7.5 Phosphate buffer and more than 100 times increases in solubility . Particle size analysis reveals that Telmisartan was dispersed in the form of nanoparticles into the PVP matrix with particles with sizes smaller than 5–10 nm. X-ray diffraction, differential scanning calorimetry and Fourier transform infrared characterization indicated the nanodispersion exhibited change in crystalline nature. Nanodispersion has been successfully formulated avoiding the need for surfactant, basic amino acid, solubilising agents like alkali hydroxide uses during formulation, there by simplifying the techniques....
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A GENERAL OVERVIEW ON AQUA GEL A NOVEL DRUG DELIVERY SYSTEM UTILIZED IN A VAST FIELD OF PHARMACEUTICAL APPLICATION
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Sarita P Ratanpara, Chintan H Trivedi, Mehul B Ranpariya
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Aqua Gel is a network of polymer chains that are water-insoluble, sometimes found as a colloidal gel in which water is the dispersion medium and also sometime they are in the form of cross linked polymer networks that absorb substantial amounts of aqueous solutions. Aqua Gels have been introduced suitable as novel materials for a variety of applications such as biomedical engineering, sanitary products, agriculture, bioseparation, enhanced oil recovery, etc. They have been successfully used as superabsorbent materials and in drug delivery, cell encapsulation and tissue repair due to their high water content and consequent biocompatibility. The rate and degree of Aqua Gel swelling are the most important parameters which control the release patterns of solvents and drugs from these polymeric networks. PH sensitive and temperature sensitive Aqua Gels can be used for site specific controlled drug delivery. Aqua Gels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. The aim of this article is to present a concise review on the applications of Aqua Gels in the pharmaceutical field, Aqua Gel properties, and method of preparation of Aqua Gel, advantages and disadvantages of Aqua Gel....
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E- ISSN: 0976-3791
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Frequency: Quarterly
E- ISSN: 0976-3791
RI Factor- 2.24
Abstracted/ Indexed in:Index Copernicus, Ulrich’s International Periodical Directory & Google Scholar, SCIRUS, Journal Seek (Genamics), PSOAR, getCITED
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