Journal Scope
Inventi Rapid/Impact: Blood is the peer reviewed journal of Health Science. It considers research and review articles on blood, circulatory system and blood disorders like anaemia, haemophilia, leukaemia and haemorrhage and blood transfusion. The journal also has the content on the current development in the field of blood, prevention, medication, diagnosis and hematology.
|
INCIDENCE OF FORMATION OF COMMON TRUNK IN HEPATIC VEINS
|
|
|
D. Singh, S. Sandeep, S. Ritu
|
|
Introduction- Liver has the unique capacity of regeneration. In the era of increasing liver surgeries, resections are gaining importance for treating conditions like hepatocellular carcinomas and split liver transplantations. This study is an attempt to provide useful assistance for hepatic surgeons in phases of operative planning and vascular control maneuvers required in liver surgery.
Materials and Methods- The study was conducted on 30 specimens of liver from well embalmed cadavers in the department of Anatomy of Dayanand Medical College and Hospital, Ludhiana and of Adesh Institute of Medical Sciences and Research, Bathinda. The livers were studied radiologically followed by dissection. The course and ramifications of major hepatic veins were studied.
Observations: Out of 30 livers studied the findings were-
There were three major hepatic veins-Right, Middle and Left.
The formation of common trunk was found only in one liver. The trunk was found between right and middle veins.
In rest of the livers , the major hepatic veins drained into Inferior Vena Cava independently.
Conclusion- Resection of liver due to tumours or fulminant failure can be complicated by massive haemorrhage or air embolism. This could be due to difficulty in identifying path of the hepatic veins. The complicated nature of liver’s vascular supply emphasizes the study of variations in their course and ramifications. This information may be useful to hepatologists, hepatic surgeons while planning segmental resection of the liver, and to radiologists planning diagnostic and interventional procedures on hepatic venous system.
Key words-hepatic veins, split liver transplantations, hepatocellular carcinomas, common trunk...
More
|
|
|
RECENT ADVANCES IN DEEP VEIN THROMBOSIS
|
|
|
NS Vyawahare, Swati Narkhede, Aditi Kotasthane*
|
|
With its significant morbidity and associated mortality, Deep vein thrombosis (DVT) presents a diagnostic and therapeutic challenge to all clinicians directly involved in patient care. In view of the shortcomings in the existing methods for the prophylaxis, diagnosis and treatment of DVT, it has been the aim of the researchers to try and come up with newer methods, with their benefits cancelling the shortcomings of the previous therapies. Recent breakthroughs in minimally invasive interventional radiology techniques such as use of indium-lll- labelled platelets and use of automated strain gauge plethysmography, however, are improving the prognosis of DVT. Also, the use of the Lympha Press Pneumatic Apparatus is being seen as an effective tool for the prophylactic treatment of DVT. With newer anticoagulants like Fondaparinux, Idraparinux, Razaxaban, Apixaban, Dabigatran, Lepirudin and techniques like the Power Pulse technique and retrievable filters, the scope for research in the management of DVT is broadening every day....
More
|
|
|
DIAMETER OF RIGHT HEPATIC VEIN AT ITS OPENING INTO INFERIOR VENA CAVA
|
|
|
Daizy Singh *, Sandeep Singh, Anupma Gupta Ritu Singh
|
|
The liver is a complex organ system that is involved in a variety of life sustaining processes.The complex development of liver and the biliary system in utero results in multiple and complicated anatomical variations.An absolute knowledge of these anatomical variations,careful dissection and identification of these structures at the time of surgery is required for the safe performance of all hepatobiliary operarions.There are three major hepatic veins-right,middle and left.The study of diameter of right hepatic vein at its opening into inferior vena cava has been undertaken on 15 livers from embalmed cadavers.The veins were studied radiologically followed by dissection.On radiology, diameter was found to be 0.8-2.4cm. Comparison couldnot be done as such a study has not been reported as yet.The results obtained by the dissection methods are in accordance with the work done by previous researchers.Diameter obtained was 0.7-2.0.Mean obtained was 1.167+ 0.358cm.Thus, this study has been done for correctly performing liver transplantation procedures and to cope up anatomic anomalies.
Keywords-hepatic veins,...
More
|
|
|
POTENTIAL USES OF CORD BLOOD IN CARDIAC SURGERY
|
|
|
Ralph S Mosca
|
|
Despite advances in the fields of prevention, medical intervention and surgical therapy, cardiovascular disease remains a major
public healthcare issue. A promising area of research is the potential application of regenerative therapies with pluripotential
stem cells to reduce the burden of heart disease and its sequelae. Umbilical cord blood, a rich source of multiple populations
of nonembryonic stem cells, will be a valuable resource and has the potential to advance therapeutic options for patients with
acquired and congenital heart disease....
More
|
|
|
REGULATION OF IMMUNE RESPONSES BY HISTONE DEACETYLASE INHIBITORS
|
|
|
Paul V Licciardi, Tom C Karagiannis
|
|
Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence
attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells.
Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA,
methylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role
of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role
of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed....
More
|
|
|
INHIBITION OF LPS-INDUCED ACTIVATION OF COAGULATION BY P38 MAPK INHIBITOR
|
|
|
Lutz Koch, Stefan Hofer, Markus A Weigand, David Frommhold, Johannes Poeschl, Peter Ruef
|
|
During Gram-negative sepsis, lipopolysaccharide (LPS) activates toll-like receptor (TLR) 4 and induces complex responses of
immune system and coagulation. However, the underlying LPS signalling mechanism on coagulation activation remains complex.
To determine the role of the intracellular signalling factors p38 mitogen-activated protein kinase (MAPK), nuclear factor-kappa
B (NF-?B), and c-Jun N-terminal kinase (JNK) in the procoagulant response to LPS, coagulation process of human whole
blood exposed to specific inhibitors was measured by thrombelastography. Samples were stimulated with LPS (100 µg/mL) after
preincubation with BAY117082 (specific NF-?B inhibitor), SP600125 (specific JNK inhibitor), SB203580 (specific p38 MAPK
inhibitor), or vehicle. SB203580 strongly inhibited LPS-induced coagulation activation, whereas BAY117082 and SP600125 showed
no significant effect. Activation of p38 MAPK, NF-?B, and JNK and respective inhibitory effects were confirmed by Multi-Target
Sandwich ELISA. In conclusion, activation of p38 MAPK is crucial for early LPS-induced activation of coagulation....
More
|
|
|
|
E- ISSN: Awaited
|
|
Frequency: Quarterly
E- ISSN: Awaited
RI Factor- 1.0
Abstracted/ Indexed in: Ulrich’s International Periodical Directory & Google Scholar, SCIRUS, getCITED
|
|