Journal Scope
Inventi Rapid/Impact: Molecular Pharmacology is the peer reviewed journal of Pharmaceutical Sciences. Molecular Pharmacology publishes articles on study of molecules involving structural biology, physiology, molecular biology, biochemistry, drug discovery, molecular medicine, behavioral pharmacology and cellular pharmacology.
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MOLECULARLY-BIOCHEMICAL AND NEUROPSYCHOPHYSIOLOGICAL ASPECTS OF NEUROPROTECTIVE ACTIVITY OF MEXIDOL DURING CHRONIC IMMOBILIZATIONAL STRESS
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I S Chekman, I Yu Yakovleva, I F Belenichev, N A Gorchakova, N V Buhtiyarova
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It is found out that in models of rats’ chronic stress an oral administration of Mexidol (100 mg/kg) during 10 days decreases a degree of DNA oxidative modification markers (8-OHG), proteins APH and KPH, hyperproduction of NO, and activity of NO-synthase. Also it changes an expression of early gene c-Fos and increases a concentration of Bcl-2 in neurons of paraventricular nuclei of the hypothalamus....
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THE POSSIBLE OPIOID RECEPTORS INDEPENDENT ANALGESICS FOR FUTURE VIA TWO NOVEL THERAPEUTIC TARGETS
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Nandha K H, Sachdeva P D
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Pain is an important yet the most troublesome physiological response able to be categorized in many types and operated by certain mechanisms. Countering pain becomes the first goal in any illness or state of injury. Opioids are the most potent analgesics under use but with serious drawbacks including physical dependence making their use to be restricted to an extent. Inhibition of nitric oxide synthesis produces analgesia evident by the experiments on L-NG-nitro arginine methyl ester, L-NAME, 1-(2-trifluoromethylphenyl) imidazole (TRIM), 7-Nitroindazole and most importantly neurotoxins from Ophiophagus Hannah(king cobra). The neurotoxins from various cobra venoms, epibatidine (an alkaloid from skin of Ecuadorian frog) and its synthetic and safer congener ABT-594 have been proved to possess prominent analgesic effect interestingly by neuronal acetyl choline receptors modulation. They are devoid of side effects and toxicities of opioids including physical dependence because of their opioid independent mechanism. Cobrotoxin is the one such product developed from cobra venom neurotoxins igniting a hope of emergence of more candidates of this category having a fair advantage over opioids with equal efficacy in future. A vast range of neurotoxins present in nature are yet to be explored for their therapeutic applicability as analgesics which may be acting either through nitric oxide synthesis inhibition or neuronal acetyl choline receptors modulation. Extensive research in this field is expected to build a new series of effective and safe analgesics....
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ENDOTHELIAL DYSFUNCTION AND THERAPY IN CARDIOVASCULAR DISEASES
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Manish Rajora, Ravi Raj Singh, Sachin Dhiman, S S Sisodia
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A layer that lines all the internal surfaces of the blood vessels is termed as endothelium. It separates circulating blood from the tissues. It helps in maintenance of vasomotor balance and vascular tissue homeostasis. It regulates the smooth muscle cells relaxation and contraction property by secretion of a large number of anti-atherosclerotic substances, the most important of them is nitric oxide (NO). Endothelium regulates homeostasis by controlling the production of prothrombotic, antithrombotic, fibrynolitics and antifibrynolitics components. Imbalance between vasodilation and vasocontraction leads to endothelial dysfunction. Endothelial dysfunction is considered as a key early event in majority of cardiovascular diseases. Oxidant stress plays an important role in altering the function of endothelial cells. Oxidant stress is excessive production of reactive oxygen species (ROS) which leads to oxidation of biological macromolecules like DNA, RNA, protein, carbohydrates and lipids. Endothelial dysfunction is involved in pathogenesis of many cardiovascular diseases i.e. diabetes, hypertension, atherosclerosis, hypercholesterolemia and heart attack. Endothelial Dysfunction therapies are effective in cardiovascular diseases....
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E- ISSN: 0976-7509
P- ISSN: 2229-4171
Inventi Impact Molecular Pharmacology
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Frequency: Quarterly
E- ISSN: 0976-7509
P- ISSN: 2229-4171
Index Copernicus: 4.30
Abstracted/ Indexed in: Index Copernicus, Ulrich’s International Periodical Directory & Google Scholar, SCIRUS, Journal Seek (Genamics), PSOAR, getCITED, JOURNAL directory
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