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Inventi Rapid: Pharm Tech
publication date: 2013/1/31

FORMULATION AND IN-VITRO EVALUATION OF ATORVASTATIN CALCIUM IMMEDIATE RELEASE PELLETS
                  G R Prasanna Laxmi*, Swetha Kruthika V, Susmitha Bezawada, B Samyutha Rani, S V Subba Rao

ABSTRACT
The study was undertaken with an aim to formulate and evaluate immediate release pellets of atorvastatin calcium by drug layering method in to order reduce dosing frequency and improve patient compliance. This is due to the fact that atorvastatin calcium which is rapidly absorbed after administration. Preformulation studies like physicochemical properties, solubility of the drug and excipient compatibility study were studied. Formulated Pellets were evaluated for pellet size, hardness, bulk density, tapped density, compressibility index, Hausner’s ratio, drug content, In-vitro dissolution, differential scanning calorimetry (DSC) analysis and release kinetics. In-vitro dissolutions were performed for all the prepared formulations. Dissolution profile of F4 (100.2±0.30%) was matched perfectly with the innovator formulation (100.31±0.43). Release kinetics indicates that all the formulations follows non- fickian diffusion mechanism. After exposing to short term stability conditions the formulation was analyzed for various evaluation parameters. Results concluded that F4 was found to be best formulation out of all six formulations. It can be concluded that the immediate release tablet was beneficial for delivering the drug which needs faster release to achieve the immediate action.

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How to Cite This Article

G R Prasanna Laxmi*, Swetha Kruthika V, Susmitha Bezawada, B Samyutha Rani, S V Subba Rao,  " FORMULATION AND IN-VITRO EVALUATION OF ATORVASTATIN CALCIUM IMMEDIATE RELEASE PELLETS ",  Inventi Rapid: Pharm Tech ,  Vol. 2013 , Article ID- " Inventi:ppt/672/13 " 2013  [ cited 2014 Jul 31 ]  Available From  


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