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Inventi Impact: Pharm Tech
publication date: 2013/4/15

PREPARATION AND EVALUATION OF MEFENAMIC ACID SOLID DISPERSIONS EMPLOYING HYDROPHILIC CARRIERS
                  R Santosh Kumar, M Anu Sonia

ABSTRACT
Mefenamic acid is a potent prostaglandin synthetase inhibitor that is used widely as a non-steriodal anti-inflammatory and analgesic–antipyretic drug. It is used in the mild to moderate pain including headache, dental pain, postoperative and postpartum pain, dysmenorrheal, osteoarthritis. However, its oral bioavailability is very low, probably due to poor solubility in water and insufficient dissolution rate. The purpose of the current study is to improve the solubility and dissolution rate of the poorly soluble drug, Mefenamic acid by solid dispersions using hydrophilic carriers like PEG (poly ethylene glycol) and PVP (Polyvinylpyrrolidine) by different methods of preparation of solid dispersions.

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How to Cite This Article

R Santosh Kumar, M Anu Sonia,  " PREPARATION AND EVALUATION OF MEFENAMIC ACID SOLID DISPERSIONS EMPLOYING HYDROPHILIC CARRIERS ",  Inventi Impact: Pharm Tech ,  Vol. 2013 , Article ID- " Inventi:ppt/655/13 " 2013  [ cited 2014 Jul 31 ]  Available From  


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