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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2013/2/8

COLORIMETRIC ESTIMATION OF LAPATINIB DITOSYLATE USING MBTH REAGENT
                  A Naveen Kumar*, P Pradeep Kumar, T E G K Murthy

ABSTRACT
Lapatinib is an orally active drug for breast cancer and other solid tumours. It is used in combination therapy for HER-2 positive breast cancer. A simple and precise calorimetric method was developed for determination of Lapatinib in pharmaceutical dosage forms using MBTH reagent. Lapatinib exhibit ? max at 661nm in solvent methanol and obeyed linearity in concentration range 2-10µg/ml. The calorimetric reagent used is MBTH and the oxidising agent used is ferric chloride. The LOQ and LOD are found to be 0.36 and 0.121 mcg/ml respectively. The method is statistically validated.

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How to Cite This Article

A Naveen Kumar*, P Pradeep Kumar, T E G K Murthy,  " COLORIMETRIC ESTIMATION OF LAPATINIB DITOSYLATE USING MBTH REAGENT ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2013 , Article ID- " Inventi:ppaqa/706/13 " 2013  [ cited 2014 Apr 24 ]  Available From  


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