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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2012/9/26

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN THEIR COMBINED TABLET DOSAGE FORM
                  Amit Shah*, Pinak Patel, Dharmendrasinh Baria, Ankit Patel, Dhruval Bhavsar

ABSTRACT
Two simple, accurate, precise and specific spectrophotometric methods have been developed for simultaneous determination of Tolperisone Hydrochloride (TOL) and Diclofenac Sodium (DFS) in its combined tablet dosage form by using methanol as a solvent. The first method is dual-wavelength method which involves estimation of TOL by absorbance difference at 267.19nm and 297.05nm, and DFS by absorbance difference at 241.26 nm and 266.4 nm. The second method is first order derivative method in which absorption at 282.12 nm (zero cross point of DFS) was used for quantification of TOL and 255.17 nm (zero cross point of TOL) for quantification of DFS. Two methods follow Beer’s linearity in the range of 10-50µg/ml for TOL and DFS both. The mean % recoveries were found to be in the range of 99.63 – 100.67 % and 98.9 – 100.7 % for TOL and DFS respectively for dual-wavelength method and in the range of 98.86 – 100.16% and 99.63 – 100.67% TOL and DFS respectively for first order derivative method. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of TOL and DFS in their combined Tablet dosage form.

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How to Cite This Article

Amit Shah*, Pinak Patel, Dharmendrasinh Baria, Ankit Patel, Dhruval Bhavsar,  " DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN THEIR COMBINED TABLET DOSAGE FORM ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2012 , Article ID- " Inventi:ppaqa/531/12 " 2012  [ cited 2014 Jul 24 ]  Available From  


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