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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2012/7/31

QUANTITATIVE ESTIMATION OF CITICOLINE SODIUM IN TABLET FORMULATION BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY & FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY USING AREA UNDER CURVE METHOD
                  P P Goti*, J J Savsani, N B Savjiyani, U V Bangoriya

ABSTRACT
Citicoline sodium is chemically Cytidine 5‘-{trihydrogendiphosphate} p‘-[2-{trimethylammonio} ethyl] ester inner salt. Citicoline sodium is primarily used in pharmacotherapy of brain insufficiency and other related neurological disorders viz., as stroke, brain trauma and Parkinsonism’s disease. Citicoline is not official in any pharmacopoeia. Few analytical methods like simple UV Spectrophotometric method, Second order Spectrophotometric methods, liquid chromatography, stability indicating HPLC, colorimetric and biological assay have been established for the estimation of Citicoline in bulk and tablet dosage form, there was no mention of a method based on AUC measurement of spectrum in Spectrophotometric estimation. The proposed UV- Visible Spectrophotometric method is based on AUC measurement of first order derivative spectra is a simple, specific, rapid, accurate and economic for quantitative estimation of Citicoline sodium. The solvent used was double distilled water. Absorption minima in first order derivative spectra was found 288nm (method-I) and area under curve was measured from 272-304nm (method-II), the drug followed a linear relationship in the range of 10-20 µg/ml while the correlation coefficient was at 0.995 & 0.998 respectively. The recovery was 99.49% ±0.50 and the coefficient of variance for intraday and interday was found to be less than 5%, LOD and LOQ for this method was found 2 µg/ml and 10 µg/ml respectively. This method is found suitable for day to day analysis of Citicoline sodium in bulk and its formulation.

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How to Cite This Article

P P Goti*, J J Savsani, N B Savjiyani, U V Bangoriya,  " QUANTITATIVE ESTIMATION OF CITICOLINE SODIUM IN TABLET FORMULATION BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY & FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY USING AREA UNDER CURVE METHOD ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2012 , Article ID- " Inventi:ppaqa/466/12 " 2012  [ cited 2014 Apr 19 ]  Available From  


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