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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2012/6/6

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM BY RP-HPLC
                  Mihir Raval*, Jasmin Chikhalia, Mital Gosai, Kashyap Thumar

ABSTRACT
A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Metoprolol succinate(MS) and Olmeartan medoxomil(OM) in marketed formulation is developed. The determination was carried out on a Hibar 250-4.6 RP18(5um) column using a mobile phase of Methanol:Water:Acetonitrile(70:20:10) pH-3.4 with ortho phosphoric acid. The flow rate was 1.0 ml/min with detection at 231 nm.The retention time for Metoprolol succinate 2.1 min and Olmeartan medoxomil 3.0 min. Metoprolol succinate and Olmeartan medoxomil showed a linear response in the concentration range of 5-30µg/ml and 2-12 µg/ml respectively. The correlation co-efficient (r2) 0.997 for Metoprolol succinate and 0.999 for Omesartan medoxomil.The results of analysis have been validated statistically and by recovery studies.The percentage recoveries obtained for Metoprolol succinate and Omesartan medoxomil ranges from 99.05-101.28%.

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How to Cite This Article

Mihir Raval*, Jasmin Chikhalia, Mital Gosai, Kashyap Thumar,  " METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM BY RP-HPLC ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2012 , Article ID- " Inventi:ppaqa/405/12 " 2012  [ cited 2014 Jul 30 ]  Available From  


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