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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2013/12/21

A NEW METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ILAPRAZOLE BY RP-HPLC METHOD
                  Satish Kumar B, Rama Mohan Reddy T, Sandhya M, Uma Maheshwara Rao, Srinivas Reddy, Satish kumar P

ABSTRACT
A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the estimation of Ilaorazole in Tablet dosage form. C18 (hypersil column) 5mm column having 250×4.6 mm id in Isocratic mode with mobile phase containing orthophosphoric acid: methanol (70:30) was used. The flow rate was 1 ml/min and effluents were monitored at 226 nm. The retention time of Ilaprazole is 4.1. The calibration curve was linear over a concentration range from 10 µg/ml-30 µg/ml for Ilaprazole.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.05865 µg/ml and 0.195503 µg/ml for Ilaprazole respectively. The developed method was fast, accurate, precise and successfully applied to estimate the amount of Ilaprazole in bulk sample and tablet dosage form so it can be used for regular quality control of the drug.

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How to Cite This Article

Satish Kumar B, Rama Mohan Reddy T, Sandhya M, Uma Maheshwara Rao, Srinivas Reddy, Satish kumar P,  " A NEW METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ILAPRAZOLE BY RP-HPLC METHOD ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2014 , Article ID- " Inventi:ppaqa/1246/13 " 2014  [ cited 2014 Apr 16 ]  Available From  


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