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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2013/5/30

ESTIMATION OF ILAPRAZOLE IN BULK DRUG AND ITS PHARMACEUTICAL DOSAGE FORM BY DIFFERENCE SPECTROPHOTOMETRIC METHOD
                  Jashmin Mansuri, Bhavin Kanani, Shital Faldu, Ketan Dadhania

ABSTRACT
Ilaprazole is a substituted benzimidazole that inhibits gastric acid secretion and used for the treatment of erosive or ulcerative GERD, DU and hypersecretory syndromes. In present work Simple, sensitive and specific spectrophotometric method were developed and validated for quantification of Ilaprazole by difference spectroscopy. Ilaprazole exhibits a substantial difference in absorbance in the two solvents that is in 0.1 M HCl and 0.1 M NaOH at 256 nm and 307 nm respectively. Beer’s law was obeyed in the concentration range of 3 to 18 µg ml-1for Ilaprazole. Results of tablet analysis showed standard deviation in the range of 99.75 % for ENL which indicate repeatability of the method. The results indicated excellent recoveries ranging from 99.23 to 99.35 %. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in the tablet formulation indicating accuracy and reliability of the method.

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How to Cite This Article

Jashmin Mansuri, Bhavin Kanani, Shital Faldu, Ketan Dadhania,  " ESTIMATION OF ILAPRAZOLE IN BULK DRUG AND ITS PHARMACEUTICAL DOSAGE FORM BY DIFFERENCE SPECTROPHOTOMETRIC METHOD ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2013 , Article ID- " Inventi:ppaqa/1061/13 " 2013  [ cited 2014 Jul 24 ]  Available From  


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