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Inventi Rapid: Planta Activa
publication date: 2011/8/30

ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF ROTULA AQUATICA LOUR ROOT.
                  Manish Kumar Gupta*, Kenganora Mruthunjaya, Laxmi Saini, Shiv Kumar Garg, A Agrawal, S Goyal

ABSTRACT
The present study was aimed to evaluate analgesic, anti-inflammatory and antipyretic activity of alcoholic and aqueous extract of root of Rotula aquatic L. in mice and rats. The alcoholic extract of R. aquatic L. root at a dose of 200 mg/kg body weight has shown significant analgesic, antipyretic and anti-inflammatory activity as compared to aqueous extract. The result of hot plate method indicated that the total alcoholic extract showed significant increase (P<0.01) in reaction time at a 3, 4 and 6 hours comparable to the reference drug Pentazocin but lesser (P<0.05) after 2 hr. The tail immersion and hot plate tests revealed that plant has high analgesic activity. Both tests showed highest degree of analgesia in alcoholic extract compared to aqueous extract. The total alcoholic extract of R. aquatic L. root at the a dose of 200 mg/kg body weight has shown significant (p<0.01) antipyretic activity as compared to aqueous extract, alcoholic extract also found to have significant result in Carrageenin-induced paw oedema; suspected mode of action may be due to possible inhibition of lipooxygenase pathway.

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How to Cite This Article

Manish Kumar Gupta*, Kenganora Mruthunjaya, Laxmi Saini, Shiv Kumar Garg, A Agrawal, S Goyal,  " ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF ROTULA AQUATICA LOUR ROOT. ",  Inventi Rapid: Planta Activa ,  Vol. 2011 , Article ID- " Inventi:ppa/37/11 " 2011  [ cited 2014 Jul 24 ]  Available From  


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