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Inventi Rapid: NDDS
publication date: 2013/8/26

PREPARATION AND EVALUATION OF SUSTAINED RELEASE PELLETS OF PREGABALIN FOR TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY
                  Farooqui Zakera, Shah Mohit, Sheorey Sonali, Shah Nirmal, Shah Jainam

ABSTRACT
The aim of this study was to formulate and evaluate sustained release pellets of highly soluble drug like Pregabalin by using matrix forming agent like Eudragit RS PO. The pellets were prepared by using Extrusion- Spheronization technique. Pregabalin is a BCS class I (highly soluble, highly permeable) drug, which makes it a good candidate, to be formulated in sustain release dosage form. The FTIR studies on the drug: polymer showed no interaction among the drug and the selected polymer. The in-vitro dissolution study was carried out in 900 ml 0.1 N HCl pH-1.2 for 2 hrs and then in 900 ml phosphate buffer 6.8 pH for 24 hrs using USP apparatus type I (Basket Type). The release studies showed that the pellets prepared by using Eudragit RS PO was able to sustain the release of Pregabalin only for 5 hours. Thus pellets prepare with Eudragit RS PO was coated with different concentration of Eudragit RS 30D and Eudragit NM 30D and were able to sustain the release of drug for 24hrs. Among different combination concentration tried for coating, Eudragit RS 30D and Eudragit NM 30D (15%, 15%) showed desired release pattern and was able to sustain the release of Pregabalin for 24 hours. Selected formulation was subjected to kinetics studies and stability studies. The release kinetics studies shows that drug release follows Zero Order and Hixon Crowell Model while value of ‘n’ showed non-fickian diffusion mechanism. Stability studies indicate that the developed formulation were stable and retained pharmaceutical properties at room temperature and 40 ± 2 ºC /75 ± 5% RH for a period of 15 days.

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How to Cite This Article

Farooqui Zakera, Shah Mohit, Sheorey Sonali, Shah Nirmal, Shah Jainam,  " PREPARATION AND EVALUATION OF SUSTAINED RELEASE PELLETS OF PREGABALIN FOR TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY ",  Inventi Rapid: NDDS ,  Vol. 2013 , Article ID- " Inventi:pndds/760/13 " 2013  [ cited 2014 Jul 31 ]  Available From  


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