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Inventi Rapid: NDDS
publication date: 2012/10/19

MOUTH DISSOLVING FREEZE-DRIED WAFER - A NOVEL DRUG DELIVERY FORMULATION: A REVIEW
                  A J Lakkad*, R C Kavar, P C Patel, K M Patel

ABSTRACT
Freeze-dried (lyophilised) wafers and solvent cast films from sodium alginate (ALG) and sodium carboxymethylcellulose (CMC) have been developed as potential drug delivery systems for mucosal surfaces including wounds. The wafers (ALG, CMC) and films (CMC) were prepared by freeze-drying and drying in air (solvent evaporation) respectively, aqueous gels of the polymers containing paracetamol as a model drug. The porous freeze-dried wafers exhibited higher drug loading and water absorption capacity than the corresponding solvent evaporated films. Moisture absorption, ease of hydration and mechanical behaviour were affected by the polymer and drug concentration. Two polymorphs of paracetamol were observed in the wafers and films, due to partial conversion of the original monoclinic to the orthorhombic polymorph during the formulation process. The results showed the potential of employing the freeze-dried wafers and solvent evaporated films in diverse mucosal applications due to their ease of hydration and based on different physical mechanical properties exhibited by both type of formulations.

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How to Cite This Article

A J Lakkad*, R C Kavar, P C Patel, K M Patel,  " MOUTH DISSOLVING FREEZE-DRIED WAFER - A NOVEL DRUG DELIVERY FORMULATION: A REVIEW ",  Inventi Rapid: NDDS ,  Vol. 2013 , Article ID- " Inventi:pndds/532/12 " 2013  [ cited 2014 Aug 21 ]  Available From  


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