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Inventi Rapid: NDDS
publication date: 2012/5/30

SOLUBILITY ENHANCEMENT OF ALBENDAZOLE BY DIFFERENT APPROACHES
                  Dhagash A Patel*, Soham M Shukla, Darshan A Modi

ABSTRACT
Purpose: Solubility enhancement of Albendazole by different approaches. Method: In Physical Mixture method various ratios of solid dispersion were prepared using Albendazole and carriers such as PVP K-30, PEG-6000, ß-CD, Sodium Lauryl Sulphate and PEG-4000 by following method. The physical mixtures of drug and carriers in 1:1 and 1:2 were prepared by mixing individual components that was previously sieved (85 #) together with a spatula. The prepared powder was been keep in self seal coven and put in to the desiccators for farther evaluation. In Kneading method the physical mixtures of drug and carriers in 1:1 and 1:2 were triturated in a mortar with a small volume of water-acetone (1:1 v/v) solution. The thick slurry was kneaded for 45 minutes and then dried at 45 ºC. The dried mass was pulverized and sieved from 85 # and fraction was collected. The prepared powder was been keep in self seal coven and put in to the desiccators for farther evaluation. In Solvent Evaporation Method the aqueous solution of carrier was added to acetone solution of drug. The resulting mixture was stirred for 1 hour and evaporated at a temperature of 45 ºC until dry. The dried mass was pulverized and sieved from 85# and fraction was collected. The prepared powder was been keep in self seal coven and put in to the desiccators for farther evaluation. In Melt Dispersion Method the different ratio of ABZ: PEG 4000 and ABZ: PEG 6000 are taken in Petridis and heated until dry residue occurs. The dried mass was pulverized and sieved from 85# and fraction was collected. Result: In vitro release data, solubility data of various batches suggests that highest solubility and in vitro drug release was found in ß-CD Solvent Evaporation method. These values are higher than that of pure drug and marketed formulations. Conclusion: The studies indicate that the solubility of Albendazole can be enhanced by different approaches, in which ß-CD Solvent Evaporation method can enhance the solubility of Albendazole maximum. So, this method can be used to formulate the dosage form.

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How to Cite This Article

Dhagash A Patel*, Soham M Shukla, Darshan A Modi,  " SOLUBILITY ENHANCEMENT OF ALBENDAZOLE BY DIFFERENT APPROACHES ",  Inventi Rapid: NDDS ,  Vol. 2012 , Article ID- " Inventi:pndds/394/12 " 2012  [ cited 2014 Jul 31 ]  Available From  


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