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Inventi Rapid: Pharm Analysis & Quality Assurance
publication date: 2011/4/26

METHOD DEVELOPMENT AND VALIDATION OF ETODOLAC IN TABLET DOSAGE FORM BY UV SPECTROSCOPY
                  P.Balan* , I. Carolin Nimila, K.Radhika, M. Lakshmi Prasanna, M. Vanaja Rani, S.Rajasekar

ABSTRACT
A simple, sensitive, specific, spectrophotometric method has been developed for the detection of etodolac in pure form and pharmaceutical formulations. The drug was examined by using acetic acid as a solvent for this study by spectrophotometrically at 273 nm and obeyed beer lamberts law in the concentration range 2-10µg/ml with correlation coefficient of 0.9972.The lower limit of detection was found to be 0.073µg/ml and the limit of quantification to be 0.021µg/ml. The percentage recovery study of the drug for the proposed method were found in the range of 100.16% w/v -100.25% w/v for brand 1 and 100.005w/v -100.16%w/v for brand 2. Results of analysis for method were validated statistically and by recovery studies. The assay results were found to be in good agreement with label claim. The proposed method was simple sensitive, precise, quick and useful for routine quality control.

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How to Cite This Article

P.Balan* , I. Carolin Nimila, K.Radhika, M. Lakshmi Prasanna, M. Vanaja Rani, S.Rajasekar,  " METHOD DEVELOPMENT AND VALIDATION OF ETODOLAC IN TABLET DOSAGE FORM BY UV SPECTROSCOPY ",  Inventi Rapid: Pharm Analysis & Quality Assurance ,  Vol. 2011 , Article ID- " Inventi:paqa/112/11 " 2011  [ cited 2014 Apr 16 ]  Available From  


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