New Site Home Editors Authors Subscribers
Inventi Journals







Inventi Impact: NDDS
publication date: 2011/4/15

GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ASPIRIN: FORMULATION AND EVALUATION OF FLOATING MICROBEADS
                  A G Pandey , S Das, S Mallick , S P Singh

ABSTRACT
The design of effective drug delivery systems has recently become an integral part of the development of new medicines. Gastro retentive drug delivery systems of Aspirin as floating microbeads were prepared with the objective to obtain site specific drug delivery, to extend its duration of action and reduce the side effects. The present study reveals the characterization of Aspirin -loaded agar floating microbead formulations. Six formulation were made depending on the percentage of the SCMC (0.2%, 0.5%, 1.0%, 1.5%, 2.0%, and3.0%). The ionotropic gelation method was used to prepare sodium carboxymethyl cellulose based controlled release agar microbeads of Aspirin . Prepared microbeads were evaluated for particle size analysis, entrapment efficiency, Stability study , Swelling index, buoyancy studies and in vitro drug release Studies . Drug – loading amount, stirring speed, curing time and polymer concentration affects the particle size .The entrapment efficiencies were found in the range of 71.85 ± 2.04 - 94.53 ± 1.02%. The particle sizes were found in the range of 0.82 ± 0.006 - 1.08 ± 0.009 mm. The invitro drug release study showed that the microbeads were prepared using 2 % SCMC had best zero order release and good sustaining effect . The data suggest that Sodium Carboxy methyl cellulose and agar is a potentially useful material for making controlled release Aspirin -loaded floating microbeads by the ionotropic gelation method.

Full Text

How to Cite This Article

A G Pandey , S Das, S Mallick , S P Singh,  " GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ASPIRIN: FORMULATION AND EVALUATION OF FLOATING MICROBEADS ",  Inventi Impact: NDDS ,  Vol. 2011 , Article ID- " Inventi:ndds/85/10 " 2011  [ cited 2014 Aug 22 ]  Available From  


Copyright@2011. Inventi Journals Pvt.Ltd. All Right Reserved.